Zambada, 76, is the leader of Mexico's Sinaloa cartel.

Attorney General Merrick Garland said: "The Justice Department has taken into custody two additional alleged leaders of the Sinaloa Cartel, one of the most violent and powerful drug trafficking organizations in the world. Ismael Zambada Garcia, or 'El Mayo,' cofounder of the Cartel, and Joaquin Guzman Lopez, a son of its other cofounder, were arrested today in El Paso, Texas."

"El Mayo and Guzman Lopez join a growing list of Sinaloa Cartel leaders and associates who the Justice Department is holding accountable in the United States,"Garland said.

Zambada was previously charged in multiple superseding indictments with running a continuing criminal enterprise, as well as murder conspiracy, money laundering conspiracy, cocaine, heroin, methamphetamine, and fentanyl manufacture and distribution conspiracy, as well as other drug-related crimes, through his continuing leadership of the Sinaloa Cartel, one of the most violent and powerful drug trafficking organizations in the world, as per a press release issued by US Department of Justice.

The fifth superseding indictment extends the end-dates of the continuing criminal enterprise and several conspiracies from May 2014 to January 2024.

Guzman Loera was convicted by a federal jury in Brooklyn in February 2019 and sentenced to life in prison plus 30 years.

Zambada Garcia has continued to evade capture, and, as alleged, continues to run the Sinaloa Cartel from Mexico.  

According to the superseding indictment, from 1989 to 2024, Zambada Garcia led a continuing criminal enterprise responsible for the importation and distribution of massive quantities of narcotics and which generated billions of dollars in profits.  

To ensure the success of the cartel, Zambada Garcia employed individuals to obtain transportation routes and warehouses to import and store narcotics, and “sicarios,” or hit men, to carry out kidnappings and murders in Mexico to retaliate against rivals who threatened the cartel.  

The millions of dollars generated from the drug sales were then transported back to Mexico.  

Guzman Loera’s name has been removed from the fifth superseding indictment in light of his 2018 trial conviction.