The toll is expected to rise as rescue workers said they fear more people are trapped under rubble.
One of the worst hit area was Juchitán, in Oaxaca, where at least 17 people died.
Speaking about the crisis, Mayor Gloria Sanchez said, "The situation is Juchitán is critical; this is the most terrible moment in its history."
The Mexican President visited the town on Friday.
Meanwhile, a tsunami warning was issued, forcing the evacuation of thousands in and around Chiapas.
However, the warning was lifted later.
According to the the BBC, Pope Francis, who's visiting Colombia, condoled the loss and said in an open air mass that he was praying "for those who have lost their lives and their families".
A similar quake in 1985 killed thousands of people in Mexico, however, the impact of the latest one is said to be greater.
Experts opined that the death toll was lesser as the quake struck less populated cities.
In Guatemala, where the quake too wreaked havoc, at least one person was reported dead.
Images: @EPN/Twitter
@CRGuatemalteca/Twitter
Screengrab from BBC